Zavyalov OA, Frolov AN.

Animal Husbandry and Fodder Production. 2026. Vol. 109. No. 2. P. 8-29.

doi: 10.33284/2658-3135-109-2-8

Review article

The effect of selenium-containing supplements on productivity and microbiota of farm animals

Oleg A Zavyalov1, Alexey N Frolov2

1,2Federal Research Centre of Biological Systems and Agrotechnologies of the Russian Academy of Sciences, Orenburg, Russia

1oleg-zavyalov83@mail.ru, https://orcid.org/0000-0003-2033-3956

2forleh@mail.ru, https://orcid.org/0000-0003-4525-2554

Abstract. Enhancing the productivity of farm animals is a key objective for ensuring food security. One of the most critical conditions for the efficiency of livestock farming is adequate mineral nutrition, particularly the supply of the essential trace element selenium to the body. Selenium deficiency leads to the development of pathologies, reduced immunity, and decreased productive traits. This paper presents a systematic analysis of current literature on the use of selenium-containing supplements in animal husbandry. The main focus is on their influence on metabolic processes, productive indicators, and the composition of the intestinal microflora in cattle, pigs, and poultry. The literature search was conducted in the RSCI, PubMed, Scopus, and Web of Science databases for the period 2000-2025. The review examines current understanding of selenium metabolism and the role of selenoproteins (glutathione peroxidase, selenoprotein P, etc.) in antioxidant defense and redox signaling. It is noted that, despite the proven effectiveness of organic forms of selenium (selenomethionine) compared to inorganic salts, the fundamental mechanisms of selenium's effect on the body, especially on the gut microbiome and the "gut-liver" axis, remain fragmentarily studied. Particular attention is paid to innovative sources of the trace element: selenium-enriched probiotics and selenium nanoparticles. It is shown that these forms not only increase the bioavailability of selenium but are also capable of modulating the composition of the intestinal microflora, increasing the abundance of beneficial bacteria (Lactobacillus, Akkermansia, Prevotella), which indirectly improves host metabolism, antioxidant status, and productivity. In conclusion, the necessity of developing reference intervals for selenium content in biological substrates for highly productive animals is substantiated, and the promising nature of using innovative forms of selenium for the targeted correction of the microbiome and improving the quality of livestock products is emphasized.

Keywords: cattle, selenium, productivity, microbiome, selenium-enriched bacteria, nanoselenium, bioavailability

Acknowledgments: the work was supported in accordance to the plan of research works for 2024-2026 FSBRI FRC BST RAS (No. FNWZ-2024-0001).

For citation: Zavyalov OA, Frolov AN. The effect of selenium-containing supplements on productivity and microbiota of farm animals (review). Animal Husbandry and Fodder Production. 2026;109(2):8-29. (In Russ.)]. https://doi.org/10.33284/2658-3135-109-2-8

References

  1. Sheida EV, Lebedev SV, Miroshnikov SA, Grechkina VV, Shoshina OV. Adaptive responses of cattle digestive system as influenced by dietary ultrafine iron particles combined with fat diets. Sel’skokhozyaistvennaya biologiya [Agricultural Biology]. 2022;57(2):328-342. doi: 10.15389/agrobiology.2022.2.328rus doi: 10.15389/agrobiology.2022.2.328eng
  2. Zavyalov OA, Medetov ES, Amirshoev FS, Gulukin AМ. Testing technology for improving the productive qualities of cattle by assessing and correcting the elemental status. Animal Husbandry and Fodder Production. 2025;108(3):8-20. https://doi.org/10.33284/2658-3135-108-3-8
  3. Soboleva NV, Duskaev GK, Sheida EV, Kvan OV, Rakhmatullin ShG. Effect of magnesium additives in the diet of dairy cows on their physiological state and productivity in the summer. Feed Production. 2025а;4:47-54. doi: 10.30906/1562-0417-2025-4-47-54
  4. Soboleva NV, Duskaev GK, Sheida EV, Kvan OV, Rakhmatullin ShG. The effect of magnesium-containing additives on the physiological state and milk productivity of Nubian goats. Veterinary medicine and feeding. 2025b;4:96-99. doi: 10.30917/ATT-VK-1814-9588-2025-4-21
  5. Duskaev GK. Analysis of the current Russian beef cattle state. Proceedings of the Kuban State Agrarian University. 2024;116:244-250. doi: 10.21515/1999-1703-116-244-250
  6. Zav’yalov OA. The eff ect of selenium supplements on selenium metabolism, performance and intestinal microbiome in farm animals (review). The Agrarian Scientific Journal. 2023;12:95-100. doi: 10.28983/asj.y2023i12pp95-100
  7. Zav’yalov OA, Medetov ES. Age peculiarities and reference intervals for concentrations of major essential and toxic elements in the wool of highly productive Aberdeen-angus bulls. Perm Agrarian Journal. 2024;1(45):71-78. doi: 10.47737/2307-2873_2024_45_71
  8. Zavyalov OA, Sleptsov II. The effect of correction of selenium and zinc concentrations in seminal fluid on the elemental composition, antioxidant status and qualitative characteristics in sperm of servicing bulls. Perm Agrarian Journal. 2023;3(43):74-82. doi: 10.47737/2307-2873_2023_43_74
  9. Sheida EV, Rakhmatullin ShG, Lebedev SV, Grechkina VV, Zavyalov OA, Frolov AN. Changes in blood parameters of broiler chickens with different nutritional security of the diet. Animal Husbandry and Fodder Production. 2021;104(4):193-204. doi:10.33284/2658-3135-104-4-12
  10. Duskaev GK, Kharlamov AV, Levakhin GI, Azhmuldinov EA, Amerkhanov KhA, Miroshnikov SA, Rysaev AF. Brief overview of beef production systems in Russia and the world (review). Animal Husbandry and Fodder Production. 2022;105(3):78-94. doi:10.33284/2658-3135-105-3-78
  11. Sheida EV, Duskaev GK, Miroshnikov SA, Miroshnikov IS, Kvan OV. The role of organic complexes of mineral elements in the metabolism of ruminant rumen. Problems of Biological, Medical and Pharmaceutical Chemistry. 2024;27(11):65-71. doi: 10.29296/25877313-2024-11-08
  12. Silin DA, Petrusha YuK, Lebedev SV. The effect of a complex of probiotics chelated forms of trace elements on zootechnical parameters, nutrient digestibility and microbiome of laying. Veterinary medicine and feeding. 2025;6:105-108. doi: 10.30917/TT-VK-1814-9588-2025-6-21
  13. Frolov AN, Zavyalov OA. The influence of season on the elemental status and productive qualities of bulls. Animal Husbandry and Fodder Production. 2024;107(4):31-40. doi: 10.33284/2658-3135-107-4-31
  14. Abuelo A, Alves-Nores V, Hernandez J, Muiño R, Benedito JL, Castillo C. Effect of parenteral antioxidant supplementation during the dry period on postpartum glucose tolerance in dairy cows. Journal of Veterinary Internal Medicine. 2016;30(3):892-898. doi: 10.1111/jvim.13922
  15. Ahmed Z, Malhi M, Soomro SA, Gandahi JA, Arijo A, Bhutto B. Dietary selenium yeast supplementation improved some villi morphological characteristics in duodenum and jejunum of young goats. The Journal of Animal and Plant Sciences. 2016;26(2):382-387.
  16. Alfian A, Yusuf M, Ako A, Toleng L, Diansyah A, Amrullah M, Rahmat R, Hasrin H. The effects of mineral mix supplementation on reproductive performance of Bali bulls. Egyptian Journal of Veterinary Sciences. 2025:1-8. doi: 10.21608/ejvs.2025.335655.2502
  17. Ardüser F, Wolffram S, Scharrer E. Active absorption of selenate by rat ileum. The Journal of Nutrition. 1985;115(9):1203-1208. doi: 10.1093/jn/115.9.1203
  18. Bamigbade GB, et al. Selenium nanoparticles stabilized by date pulp polysaccharides: bioactivities, gut microbiota modulation and short chain fatty acids production. International Journal of Biological Macromolecules. 2025;332(Pt 2):148387. doi: 10.1016/j.ijbiomac.2025.148387
  19. Boostani A, Sadeghi AA, Mousavi SN, Chamani M, Kashan N. Effects of organic, inorganic, and nano-Se on growth performance, antioxidant capacity, cellular and humoral immune responses in broiler chickens exposed to oxidative stress. Livestock Science. 2015;178:330-336. doi: 10.1016/j.livsci.2015.05.004
  20. Ceballos A, Sánchez J, Stryhn H, Montgomery JB, Barkema HW, Wichtel JJ. Meta-analysis of the effect of oral selenium supplementation on milk selenium concentration in cattle. Journal of Dairy Science. 2009;92(1):324-342. doi: 10.3168/jds.2008-1545
  21. Chen S, Xue Y, Shen Y, Ju H, Zhang X, Liu J, Wang Y. Effects of different selenium sources on duodenum and jejunum tight junction network and growth performance of broilers in a model of fluorine-induced chronic oxidative stress. Poultry Science. 2022;101(3):101664. doi: 10.1016/j.psj.2021.101664
  22. Chen W, Zhu H, Deng R, Qiao Y, Ruan Q, Zhang J, Zhang Y, Niu Y, Xu H, Cao W. Modified melanin for intestinal radioprotection via oral administration. Cell Biomaterials. 2025;1(11):100214. doi: 10.1016/j.celbio.2025.100214
  23. Colque Caro L, Medina D, Avellaneda-Cáceres A, Aguirre L, Sandoval G, Micheloud J. Acute nutritional muscular dystrophy and mortality associated with selenium deficiency in artificial rearing of dairy calves in Salta, Argentina. Revista de Investigaciones Agropecuarias. 2024;2:86478736010. doi: 10.58149/thjm-sw46
  24. Dalia AM, Loh TC, Sazili AQ, Jahromi MF, Samsudin AA. The effect of dietary bacterial organic selenium on growth performance, antioxidant capacity, and selenoproteins gene expression in broiler chickens. BMC Veterinary Research. 2017;13(1): doi: 10.1186/s12917-017-1159-4
  25. Davis CD, Tsuji PA, Milner JA. Selenoproteins and cancer prevention. Annual Review of Nutrition. 2012;32:73-95. doi: 10.1146/annurev-nutr-071811-150740
  26. Elgendey F, Al Wakeel RA, Hemeda SA, Elshwash AM, Fadl SE, Abdelazim AM, Alhujaily M, Khalifa OA. Selenium and/or vitamin E upregulate the antioxidant gene expression and parameters in broilers. BMC Veterinary Research. 2022;18(1): doi: 10.1186/s12917-022-03411-4
  27. Ferroudj A, El-Ramady H, Prokisch J. Applications of nano-selenium in the poultry industry: an overview. Nanomaterials. 2026;16(2):142. doi: 10.3390/nano16020142
  28. Gan F, Ren F, Chen X, Lv C, Pan C, Ye G, Shi J, Shi X, Zhou H, Shituleni SA, Huang K. Effects of selenium-enriched probiotics on heat shock protein mRNA levels in piglet under heat stress conditions. Journal of Agricultural and Food Chemistry. 2013;61(10):2385-2391. doi: 10.1021/jf300249j
  29. García-Vaquero M, López-Alonso M, Benedito JL, Hernández J, Gutiérrez B, Miranda M. Influence of Cu supplementation on toxic and essential trace element status in intensive reared beef cattle. Food and Chemical Toxicology. 2011;49(12):3358-3366. doi: 10.1016/j.fct.2011.09.013
  30. Grossi S, Rossi L, De Marco M, Sgoifo Rossi CA. The effect of different sources of selenium supplementation on the meat quality traits of young Charolaise bulls during the finishing phase. Antioxidants. 2021;10(4): doi: 10.3390/antiox10040596
  31. Hefnawy AE, Tortora-Perez JL. The importance  of  selenium  and  the  effects of  its  deficiency  in  animal    Small  Ruminant  Research.  2010;89(2-3):185-192. doi: 10.1016/j.smallrumres.2009.12.042
  32. Jiang Z, Wang Z, Zhao Y, Peng M. Unveiling the vital role of soil microorganisms in selenium cycling: a review. Frontiers in Microbiology. 2024;15:1448539. doi: 10.3389/fmicb.2024.1448539
  33. Kalashnikov VV, Zajcev AM, Atroshchenko MM, Miroshnikov SA, Zavyalov OA, Frolov AN, Skalny AV. Assessment of gender effects and reference values of mane hair trace element content in English thoroughbred horses (North Caucasus, Russia) using ICP-DRC-MS. Biological Trace Element Research. 2019;191(2):382-388. doi: 10.1007/s12011-019-1634-9
  34. Khalifa OA, Al Wakeel RA, Hemeda SA, Abdel-Daim MM, Albadrani GM, El Askary A, Fadl SE, Elgendey F. The impact of vitamin E and/or selenium dietary supplementation on growth parameters and expression levels of the growth-related genes in broilers. BMC Veterinary Research. 2021;17(1):251. doi: 10.1186/s12917-021-02963-1
  35. Koppo K, Valle C, Šiklová-Vítková M, Czudková E, de Glisezinski I, van de Voorde J, Langin D, Štich V. Expression of lipolytic genes in adipose tissue is differentially regulated during multiple phases  of  dietary  intervention  in  obese    Physiological  Research. 2013;62(5):527-535. doi: 10.33549/physiolres.932483
  36. Lebedev S, Zavyalov O, Frolov A. Age features and reference intervals for the concentrations of  some  essential  and  toxic  elements  in  laying hens. Veterinary World. 2022;15(4):943-952. doi: 10.14202/vetworld.2022.943-952
  37. Li D, Xie M, Fei D, Guang Y, Zhou Y. Different forms of selenium improve laying performance and ovarian antioxidant capacity: regulating gut microbiota and ovarian metabolism. Poultry Science. 2025;104(12):106081. doi: 10.1016/j.psj.2025.106081
  38. Li Q, Li Y, Cong X, Chen S, Liu Y, Liu Y, Liu L, Yan Z, Wang Y. Distribution and bioaccessibility of selenium and selenium speciation in selenium-enriched piglets. Food Bioscience. 2024;58:103827. doi: 10.1016/j.fbio.2024.103827
  39. Liang S, Yu J, Zhao M, Chen S, Lu X, Ye F, Chen J, Zhao G, Lei L. In vitro digestion and fecal fermentation of selenocompounds: impact on gut microbiota, antioxidant activity, and short-chain fatty acids. Food Research International. 2024;180:114089. doi: 10.1016/j.foodres.2024.114089
  40. Luo L, Hou X,  Yi D,  Deng G, Wang Z, Peng M. Selenium-enriched microorganisms: metabolism, production, and applications. Microorganisms. 2025;13(8):1849. doi: 10.3390/microorganisms13081849
  41. Majors C, Myers A, Kasimanickam R. Selenium in cattle diseases and reproductive health. Clinical Theriogenology. 2025;17:12015. doi: 10.58292/CT.v17.12015
  42. Malik Z, Marghazani I, Chachar B, Shah Q, Shah T, Mengal B, Ujjan N, Bilal M. Exploring the nutraceutical role of selenium nanoparticles on laying performance, egg attributes and immune response in laying hens. Indus Journal of Bioscience Research. 2025;3:524-531. doi: 10.70749/ijbr.v3i5.1365
  43. Mehdi Y, Clinquart A, Hornick JL, Cabaraux JF, Istasse L, Dufrasne I. Meat composition and quality of young growing Belgian Blue bulls offered a fattening diet with selenium enriched cereals. Canadian Journal of Animal Science. 2015;95:465-473. doi: 10.4141/cjas-2014-114
  44. Mehdi Y, Dufrasne I. Selenium in cattle: a review. Molecules. 2016;21(4):545. doi: 10.3390/molecules21040545
  45. Mei J, Shi X, Chen M, Li Z, Cui Y, Fang C, Wu X, Chen X, Zeng K, Yang L. Chitosan/selenium nanoparticles Pickering emulsion prolong quercetin retention time to ameliorates cognitive disorder: Focus on restoring the metabolic disorder and gut microbiota. Carbohydrate Polymers. 2026;375:124804. doi: 10.1016/j.carbpol.2025.124804
  46. Michigan State University Extension. White muscle disease caused by nutrient deficiency. Western Livestock Journal. 2024. [Internet] Available from: https://www.wlj.net/white-muscle-disease-caused-by-nutrient-deficiency/ / (cited 24 Feb 2026).
  47. Miroshnikov SA, Zavyalov OA, Frolov AN, Bolodurina IP, Skalny AV, Kalashnikov VV, Grabeklis AR, Tinkov AA. The reference intervals of hair trace element content in Hereford cows and heifers (Bos taurus). Biological Trace Element Research. 2017;180(1):56-62. doi: 10.1007/s12011-017-0991-5
  48. Miroshnikov SA, Zavyalov OA, Frolov AN, Skalny AV, Grabeklis AR. The reference values of hair content of trace elements in dairy cows of Holstein breed. Biological Trace Element Research. 2020;194(1):145-151. doi: 10.1007/s12011-019-01768-6
  49. Muhammad AI, Dalia AAM, Hemly NIM, Zainudin NN, Samsudin AA. Biofortified bacteria: the role of selenium-enriched microorganisms in enhancing animal selenium uptake – a review. Journal of Animal Physiology and Animal Nutrition. 2025;109(6):1298-1320. doi: 10.1111/jpn.70001
  50. Muñiz-Naveiro O, Domínguez-González R, Bermejo-Barrera A, Bermejo-Barrera P, Cocho JA, Fraga JM. Selenium speciation in cow milk obtained after supplementation with different selenium forms to the cow feed using liquid chromatography coupled with hydride generation-atomic fluorescence spectrometry. Talanta. 2007;71(4):1587-1593. doi: 10.1016/j.talanta.2006.07.040
  51. Netto AS, Zanetti MA, Claro GR, de Melo MP, Vilela FG, Correa LB. Effects of copper and selenium supplementation on performance and lipid metabolism in confined Brangus bulls. Asian-Australasian Journal of Animal Sciences. 2014;27(4):488-494. doi: 10.5713/ajas.2013.13400
  52. Nickel A, Kottra G, Schmidt G, Danier J, Hofmann T, Daniel H. Characteristics of transport of selenoamino acids by epithelial amino acid transporters. Chemico-Biological Interactions. 2009;177(3):234-241. doi: 10.1016/j.cbi.2008.09.008
  53. Noruzi S, Torki M, Mohammadi H. Effects of supplementing diet with Thyme (Thymus vulgaris L.) essential oil and/or selenium yeast on production performance and blood variables of broiler chickens. Veterinary Medicine and Science. 2022;8(3):1137-1145. doi: 10.1002/vms3.736
  54. Papp LV, Holmgren A, Khanna KK. Selenium and selenoproteins in health and disease. Antioxidants & Redox Signaling. 2010;12(7):793-795. doi: 10.1089/ars.2009.2973
  55. Pereira ASC, Santos  MVD,  Aferri  G,  Corte RRPDS, De Freitas Júnior JE, Leme PR, Rennó FP. Lipid and selenium sources on fatty acid composition of intramuscular fat and muscle selenium concentration of Nellore steers. Revista Brasileira de Zootecnia. 2012;41:2357-2363. doi: 10.1590/S1516-35982012001100009
  56. Qiao L, Dou X, Song X, Chang J, Zeng X, Zhu L, Yi H, Xu C. Replacing dietary sodium selenite with biogenic selenium nanoparticles improves the growth performance and gut health of early-weaned piglets. Animal Nutrition. 2023;15:99-113. doi: 10.1016/j.aninu.2023.08.003
  57. Rehman R, Sial N, Ismail A, Hussain S, Abid S, Javed M, Nadeem K, Ayoub M. Growth response in Oryctolagus cuniculus to selenium toxicity exposure ameliorated with vitamin E. BioMed Research International. 2022;2022: doi: 10.1155/2022/8216685
  58. Rezaei-Ahvanooei MR, Lamanna M, Colleluori R, Formigoni A, Norouzian MA, Assadi-Alamouti A, Cavallini D. Effects of microminerals on performance and metabolic adaptation in heat-stressed dairy cows: a review. Biological Trace Element Research. 2025;204:3504-3521. doi: 10.1007/s12011-025-04911-8
  59. Salles MSV, Zanetti MA, Junior LCR, Salles FA, Azzolini AECS, Soares EM, Faccioli LH, Valim YML. Performance and immune response of suckling calves fed organic selenium. Animal Feed Science and Technology. 2014;188:28-35. doi: 10.1016/j.anifeedsci.2013.11.008
  60. Schöne F, Steinhöfel O,  Weigel K, Bergmann H, Herzog E, Dunkel S, Kirmse R, Leiterer M. Selenium in feedstuffs and rations for dairy cows including a view of the food chain up to the consumer. Journal für Verbraucherschutz und Lebensmittelsicherheit. 2013;8:271-280. doi: 10.1007/s00003-013-0827-y
  61. Selmani A, Matijaković Mlinarić N, Falsone SF, Vidaković I, Leitinger G, Delač I, Radatović B, Nemet I, Rončević S, Bernkop-Schnürch A, Vuletić T, Kornmueller K, Roblegg E, Prassl R. Simulated gastrointestinal fluids impact the stability of polymer-functionalized selenium nanoparticles: physicochemical aspects. International Journal of Nanomedicine. 2024;19:13485-13505. doi: 10.2147/IJN.S483253
  62. Sgoifo Rossi CA, Compiani R, Baldi G, Muraro M, Marden JP, Rossi R, Pastorelli G, Corino C, Dell'Orto V. Organic selenium supplementation improves growth parameters, immune and antioxidant status of newly received beef cattle. Journal of Animal and Feed Sciences. 2017;26(2):100-108. doi: 10.22358/jafs/70765/2017
  63. Shabani R, Fakhraei J, Yarahmadi HM, Seidavi A. Effect of different sources of selenium on performance and characteristics of immune system of broiler chickens. Revista Brasileira de Zootecnia. 2019;48: doi: 10.1590/rbz4820180256
  64. Sheweita SA, El-Dafrawi YA, El-Ghalid OA, Ghoneim AA, Wahid A. Antioxidants (selenium and garlic) alleviated the adverse effects of tramadol on the reproductive system and oxidative stress markers in male rabbits. Scientific Reports. 2022;12(1): doi: 10.1038/s41598-022-16862-4
  65. Singh VP, Sahu DS, Singh MK, Manoj J. Effect of supplementation of selenium and Ashwagandha (Withania somnifera) on some haematological and immunological parameters of broiler chickens. Scholars Journal of Agriculture and Veterinary Sciences. 2016;3(6):406-410. doi: 21276/sjavs.2016.3.6.2
  66. Soliman ES, Mahmoud FF, Fadel MA, Hamad RT. Prophylactic impact of nano-selenium on performance, carcasses quality, and tissues' selenium concentration using reversed-phase high-performance liquid chromatography during microbial challenge in broiler chickens. Veterinary World. 2020;13(9):1780-1797. doi: 10.14202/vetworld.2020.1780-1797
  67. Sun LL, Gao ST, Wang K, Xu JC, Sanz-Fernandez MV, Baumgard LH, Bu DP. Effects of source on bioavailability of selenium, antioxidant status, and performance in lactating dairy cows during oxidative stress-inducing conditions. Journal of Dairy Science. 2019;102(1):311-319. doi: 10.3168/jds.2018-14974
  68. Sun Z, Wu K, Feng C, Lei XG. Selenium-dependent glutathione peroxidase 1 regulates transcription of elongase 3 in murine tissues. Free Radical Biology and Medicine. 2023;208:708-717. doi: 10.1016/j.freeradbiomed.2023.09.010
  69. Tong C, Peng L, Li-Hui Y, Lin L, Kang L, Yueli C. Selenium-rich yeast attenuates ochratoxin A-induced small intestinal injury in broiler chickens by activating the Nrf2 pathway and inhibiting NF-κB activation. Journal of Functional Foods. 2020;66: doi: 10.1016/j.jff.2020.103784
  70. Wang L, Song L, Wang P, Zhang H, Li Y, Song J, Zhong L, Liu C, Zhang W, Wen P. Bioreduction of Se(IV) by Lactiplantibacillus plantarum NML21 and synthesis of selenium nanospheres Se(0). Food Chemistry. 2024;452: doi: 10.1016/j.foodchem.2024.139595
  71. Wang X, Zhong Y, Zhu Z, Zhang N, Chen X, Wang F, Wang L, Chen C, He J, Li S. Gut microbiota: a new perspective for bioavailability of selenium and human health. npj Science of Food. 2025;9(1): 228. doi: 10.1038/s41538-025-00589-3
  72. Wolffram S, Anliker E, Scharrer E. Uptake of selenate and selenite by isolated intestinal brush border membrane vesicles from pig, sheep, and rat. Biological Trace Element Research. 1986;10(4):293-306. doi: 10.1007/BF02802397
  73. Wolffram S, Grenacher B, Scharrer E. Transport of selenate and sulphate across the intestinal brush-border membrane of pig jejunum by two common mechanisms. Quarterly Journal of Experimental Physiology. 1988;73(1):103-111. doi: 10.1113/expphysiol.1988.sp003107
  74. Xu X, Wei Y, Zhang Y, Jing X, Cong X, Gao Q, Cheng S, Zhu Z, Zhu H, Zhao J, Liu Y. A new selenium source from Se-enriched Cardamine violifolia improves growth performance, anti-oxidative capacity and meat quality in broilers. Frontiers in Nutrition. 2022;9: doi: 10.3389/fnut.2022.996932
  75. Yang X, Yang C, Tang D, Yu Q, Zhang L. Effects of dietary supplementation with selenium yeast and jujube powder on mitochondrial oxidative damage and apoptosis of chicken. Poultry Science. 2022;101(10): doi: 10.1016/j.psj.2022.102072
  76. Ying Z, Xie S, Xiu Z, Sun Y, Yang Q, Gao H, Fan W, Wu Y. Under heat stress conditions, selenium nanoparticles promote lactation through modulation of rumen microbiota and metabolic processes in dairy goats. Scientific Reports. 2025;15: doi: 10.1038/s41598-025-93710-1
  77. Żarczyńska K, Sobiech P, Radwińska J, Rękawek W. Effects of selenium on animal health. Journal of Elementology. 2013;18(2):329-340. doi: 10.5601/jelem.2013.18.2.12
  78. Zavyalov OA, Medetov ES, Kurilkin YaY. Selenium and zinc supplements combined with methionine: effects on blood element profiles meat production and quality in Aberdeen-Angus bulls with selenium and zinc imbalance. Journal of Siberian Federal University. Biology. 2025;18(2):216-235.
  79. Zhang DG, Xu XJ, Pantopoulos K, Zhao T, Zheng H, Luo Z. HSF1-SELENOS pathway mediated dietary inorganic Se-induced lipogenesis via the up-regulation of PPARγ expression in yellow catfish. Biochimica et Biophysica Acta (BBA) – Gene Regulatory Mechanisms. 2022;1865(3):194802. doi: 10.1016/j.bbagrm.2022.194802
  80. Zhang J, Yang X, Ji T, Wen C, Ye Z, Liu X, Liang L, Liu G, Xu X. Digestion and absorption properties of Lycium barbarum polysaccharides stabilized selenium nanoparticles. Food Chemistry. 2022;373(Pt B): doi: 10.1016/j.foodchem.2021.131637
  81. Zhao Z, Barcus M, Kim J, Lum KL, Mills C, Lei XG. High dietary selenium intake alters lipid metabolism and protein synthesis in liver and muscle of pigs. The Journal of Nutrition. 2016;146(9):1625-1633. doi: 10.3945/jn.116.229955

Information about the authors:

Oleg A Zavyalov, Dr. Sci. (Biology), Leading Researcher, Department of Technology of Beef Cattle Breeding and Beef Production, Federal Research Centre of Biological Systems and Agrotechnologies of the Russian Academy of Sciences, 29, 9 Yanvarya St., 460000, Orenburg, Russia, tel.: 8(3532)30-81-70.

Alexey N Frolov, Dr. Sci. (Biology), Leading Researcher, Department of Technology of Beef Cattle Breeding and Beef Production, Federal Research Centre of Biological Systems and Agrotechnologies of the Russian Academy of Sciences, 29, 9 Yanvarya St., 460000, Orenburg, Russia, tel.: 8(3532)30-81-70.

The article was submitted 26.02.2026; approved after reviewing 25.05.2026; accepted for publication 15.06.2026.

Download