Lyudmila V Vlasenko, Dianna B Kosyan

 DOI: 10.33284/2658-3135-104-2-8

UDC 579.66


Research was carried out according the plan of research scientific works on 2021-2023 yy. FSBSI FRC BST RAS (No 0526-2019-0002)

Metal nanoparticles as potential inhibitors of «Quorum sensing» systems in bacteria (review)

                                             Lyudmila V Vlasenko, Dianna B Kosyan

Federal Research Centre of Biological System and Agrotechnologies of the Russian Academy of Sciences (Orenburg, Russia)

Summary. The study of inhibitors of «Quorum sensing» system is currently an important area of research. Compounds that are able to block the «quorum sensing» system can be used as new antibacterial agents, since they are mainly involved in regulating the virulence of drug-resistant pathogenic bacteria. Potential inhibitors of the «quorum sensing» system are metal nanoparticles. This activity is described for silver, gold, titanium dioxide, silicium dioxide, and zinc oxide nanoparticles. The review presents a generalized material containing modern information from foreign authors on the use of nanoparticles as inhibitors of the «quorum sensing» system in bacteria.

Key words: quorum sensing, pathogenic bacteria, biofilms, nanoparticles.


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Vlasenko Lyudmila Viktorovna, Junior Researcher, I.O. Head of the Laboratory of Selection and Genetic Research in Livestock Breeding, Federal Research Centre of Biological Systems and Agricultural Technologies of the Russian Academy of Sciences, 460000, Orenburg, 29 9 Yanuarya st., tel .: 8-922-865-77-71, e-mail:

Kosyan Dianna Bagdasarovna, Cand. Sci. (Biol.), I.O. Head of the Laboratory of Selection and Genetic Research in Livestock Breeding, Federal Research Centre of Biological Systems and Agricultural Technologies of the Russian Academy of Sciences, 460000, Orenburg, 29 9 Yanuarya st., tel .: +79228448915, e-mail:

Received: 26 May 2021; Accepted: 15 June 2021; Published: 30 June 2021