Veronika V Kozhukhovskaya, Olga S Zaitseva, Nikolay A Martynov, Vladlena D Zubareva

DOI: 10.33284/2658-3135-104-3-155

UDC 636.082

Lethal haplotypes in the population of the holstein cattle and their role in reproduction (review)

 Veronika V Kozhukhovskaya, Olga S Zaitseva, Nikolay A Martynov, Vladlena D Zubareva

Ural Federal Agrarian Research Center of the Ural Branch of the Russian Academy of Sciences

(Yekaterinburg, Russia)

Abstract. In modern populations of the Holstein cattle, there is a tendency towards a decrease in genetic diversity and a natural distribution of lethal haplotypes. Lethal mutations CVM, BLAD and brachispinal syndrome, causing significant economic losses associated with impaired reproductive system of cows and embryonic and postembryonic mortality are of the greatest interest. CVM syndrome is manifested by multiple anomalies and deformities of the skeleton of aborted fetuses and newborn calves. BLAD-mutation leads to disruption of the body's immune response to infectious agents and, in most cases, is fatal in the first months of the calf's life. Brachispinal syndrome manifests itself as a significant decrease in body weight, scoliosis and shortening of the spine, and leads to abortion and stillbirth.

Keywords: cattle, Holstein breed, lethal haplotype, CVM, BLAD, brachyspina.

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Kozhukhovskaya Veronika Valentinovna, Junior Researcher of the Department of Veterinary and Laboratory Diagnostics with a Testing Laboratory, Ural Federal Agrarian Research Centre of Ural Branch of the Russian Academy of Sciences (FGBNU UrFANITS UB RAS), 620142, Yekaterinburg, Russia, Belinsky St., 112a, tel: 8 (343) 2572044; e-mail: info@urnivi.ru

Zaitseva Olga Sergeevna, Cand. Sci. (Vet.), Senior Researcher, Laboratory of Genomic Research and Animal Breeding, Ural Federal Agrarian Research Centre of Ural Branch of the Russian Academy of Sciences (FGBNU UrFANITS UB RAS), 620142, Yekaterinburg, Russia, Belinsky St., 112a, tel: 8 (343) 2572044; e-mail: info@urnivi.ru

Martynov Nikolay Aleksandrovich, Laboratory Assistant of the Laboratory of Genomic Research and Animal Breeding, Ural Federal Agrarian Research Centre of Ural Branch of the Russian Academy of Sciences (FGBNU UrFANITS UB RAS), 620142, Yekaterinburg, Russia, Belinsky St., 112a, cell: 8(343)2572044; e-mail: info@urnivi.ru

Zubareva Vladlena Dmitrievna, Senior Specialist, Laboratory of Genomic Research and Animal Breeding, Ural Federal Agrarian Research Centre of Ural Branch of the Russian Academy of Sciences (FGBNU UrFANITS UB RAS), 620142, Yekaterinburg, Russia, Belinsky St., 112a, cell: 8 (343) 2572044; e-mail: info@urnivi.ru

Received: 9 August 2021; Accepted: 13 September 2021; Published: 30 September 2021

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