Marina Kurilkina, Oleg Zavyalov, Ksenia Atlanderova, Tatyana Kholodilina

Assessment of the digestibility and bioavailability of organometallic complexes extruded

on «in vitro» and «in situ» models

DOI: 10.33284/2658-3135-103-1-8

UDC 636.085:577.17:636.088.31

Acknowledgements:

Research was carried out according the plan of research scientific works on 2019-2021 yy. FSBSI FRC BST RAS (No 0761-2019-0005)

Assessment of the digestibility and bioavailability of organometallic complexes extruded

on «in vitro» and «in situ» models

Marina Ya Kurilkina, Oleg A Zavyalov, Ksenia N Atlanderova, Tatyana N Kholodilina

Federal Research Centre of Biological Systems and Agrotechnologies of the Russian Academy of Sciences (Orenburg, Russia)

Summary. The article presents the results of studies evaluating physical and biological properties of extruded feed additives, consisting of wheat bran and highly dispersed powders (HDP) of metals: Cu, Fe, Zn, СаСО3. It was found that the use of extruded wheat bran in combination with HDP changes structural and chemical composition of the experimental complex, contributing to an increase in the digestibility of nutrients in the in vitro experiment from 64.2 to 78.2%, while it is accompanied by an increase in bioavailability of mineral substances from feed product, Zn by 21.6%, Cu – 2.98 and Fe – 7.3% (P≤0.05). The introduction of HDP (Cu, Fe, Zn, СаСО3) during the extrusion of feed substrates is accompanied by an increase in the bioavailability of trace elements from the experimental extrudate into animal organism using in situ model, with Cu dynamics by 13% (P≤0.05) after three hours, 9.9% (P≤0.05) after 6 hours, by Fe by 4.2% and 3.1% (P≤0.05) after three and six hours, by Zn by 8.5% and 6.4% (P≤0.05) after three and six hours, respectively. As part of the studies, it was also found that an increase in the digestibility of dry matter occurs by increasing the porosity of feed substrates.

The positive effect of the studied fine particles on the bioavailability of mineral substances from experimental feed substrates into the animal organism shows the prospects for their use in animal husbandry.

Key words: cattle, bulls, Kazakh white-headed breed, feed, finely divided metal powders, wheat bran, extrusion processing, porosity, digestibility, bioavailability.

References

  1. Atlanderova KN, Makaeva AM, Kurilkina MYa. Prospects for the use of ultrafine particles in feeding of young cattle (Conference proceedings) Nanotechnology in agriculture: prospects and risks: international materials of scientific-practical conf. edited by RAS Corr. Memb. Miroshnikov SA, (Orenburg, September 26-27, 2018). Orenburg: Publishing House of the Federal State Budget Research Institution Federal Research Centre of BST RAS; 2018:46-50.
  2. Deryabin DG, Aleshina ES, Deryabina TD, Efremova LV. Biological activity of ions, nano- and micro-sized Cu and Fe particles determined with a bioluminescence inhibition assay. Problems of Biological, Medical and Pharmaceutical Chemistry. 2011;6:31-36.
  3. Lebedev SV, Gavrish IA, Gubajdullina IZ, Shabunin SV. Effects caused by different doses of dietary chromium nanoparticles fed to broiler chickens Sel’skokhozyaistvennaya Biologiya [Agricultural Biology]. 2019;54(4):820-831. (In Russ)]. doi: 10.15389/agrobiology.2019.4.820eng
  4. Kurilkina MYa, Kholodilina TN, Muslyumova DM, Atlanderova KN, Zavyalov OA. The effect of finely dispersed metal particles on the digestibility of nutrients and energy exchange in the body of young cattle. Herald of Beef Cattle Breeding. 2017;4(100):197-201.
  5. Duskaev GK, Karimov IF. Some recommendations and developments for use in feeding cattle (Conference proceedings) Beef cattle breeding – priorities and development prospects: international materials of scientific-practical conf. ed. RAS Corr. member Miroshnikov SA. (Orenburg, April 25-27, 2018). Orenburg: Publishing House of the Federal State Budget Research Institution of Federal Research Centre of BST RAS; 2018:167-175.
  6. Bogoslovskaya OA, Sizova EA, Polyakova VC, Miroshnikov SA, Leipunsky IO, Olkhovskaya IP, Glushchenko NN. Studying of safety of copper nanoparticles introduction with different physical-chemical characteristics into animals’ organism. Vestnik of the Orenburg State University. 2009;2(96):124-127.
  7. Timanova AS, Miroshnikov SA, Sokolova OYа, Kholodilina TN. Ispol’zovanie klinkernoi pyli kak faktora sposobstvuyushchego povysheniyu biologicheskoi dostupnosti veshchestv ekstrudatov. Vestnik of the Orenburg State University. Bioelementology application. 2006;12S(62):256-257.
  8. Yausheva EV, Zelepukhin AG, Ryabov NI, Kvan OV, Ramenskii VA, Zaveryukha AH, Sirazetdinov FH. Study of metal nanoparticlesas a source of micronutrient for animals. Modern Problems of Science and Education. 2013;5:470.
  9. Kalnitsky BD. The effectiveness of the use of mineral mixtures and tests to control the provision of animals with mineral elements: a guide to feed additives. Minsk: Urajay; 1990:190-194.
  10. Miroshnikov SA, Lebedev SV, Khvan OV, Rakhmatullin ShG. K metodike formirovaniya odnorodnykh grupp zhivotnykh po elementnomu status. Vestnik of the Orenburg State University. Bioelementology application. 2006;2S(52):45-46.
  11. Lebedev SV, Barysheva ES, Malysheva NV. Stepen’ nakopleniya i osobennosti vzaimodeistviya toksichnykh i essentsial’nykh elementov v organizme laboratornykh zhivotnykh (eksperimental’nye issledovaniya). Vestnik of the Orenburg State University. Bioelementology application. 2006;2S(52):33-35.
  12. Lebedev SV. Peculiarities of influence of Сd, I, Se и Zn microelements additional introduction into hen-layers ration on makroelementary structure of eggs. Vestnik of the Orenburg State University. 2009;12:96-98.
  13. Miroshnikov SА, Sizova EA. Nanomaterials in animal husbandry (review). Herald of Beef Cattle Breeding. 2017;3(99):7-22.
  14. MP 1.2.2566-09. Safety assessment of nanomaterials in vitro and in model systems in vivo. Enter 2009-12-10. Moscow, 2009:71 p.
  15. Nazarova AA, Polishchuk SD. The effect of nanocrystalline iron on mineral metabolism in animals. (Conference proceedings) Collection of thesis. doc. participants of the Second Int. competition scientific. works of young scientists in the field of nanotechnology. Moscow, 2009:790-792.
  16. Samokhin VT. Prevention of metabolic disorders in microelements in animals. 2nd ed., Ext. Voronezh: Voronezh. GAU; 2003:136 p.
  17. Sizova EA. Comparative analysis of the different-sized copper and iron nanoparticles biological effects. Vestnik of the Russian Agricultural Science. 2017;3:13-17.
  18. Sizova EA, Yausheva EV. Comparative productivity of broiler chickens injected with variously sized ultrafine iron particles. Animal Husbandry and Fodder Production. 2019;102(1):6-21. doi: 10.33284/2658-3135-102-1-6
  19. Sizova ЕА, Miroshnikov SА, Lebedev SV, Levakhin YuI, Babicheva IА, Kosilov VI. Comparative tests of various sources of microelements in feeding chicken-broilers. Sel’skokhozyaistvennaya Biologia [Agricultural Biology]. 2018;53(2):393- 403. doi: 10.15389/agrobiology.2018.2.393eng
  20. Makaeva AM, Atlanderova KN, Sizova EA, Miroshnikov SA, Vanshin VV. The elemental and microecological composition of rumen after use of highly dispersive particles in cattle feeding. Animal Husbandry and Fodder Production. 2019;102(3):19-32. (In Russ)]. doi: 10.33284/2658-3135-102-3-19
  21. Gorlov IF, Levakhin VI, Radchikov VF, Tsai VP, Bozhkova SE. Effect of feeding with organic microelement complex on blood composition and beef production of young cattle. Modern Applied Science. 2015;9(10):8-16. doi: 10.5539/mas.v9n10p8
  22. Fisinin VI, Miroshnikov SА, Sizova ЕА, Ushakov АS, Miroshnikova ЕP. Metal particles as trace-element sources: Current state and future prospects. World’s Poultry Science Journal. 2018;74(3):523-540.
  23. Makaeva A, Atlanderova K, Miroshnikov S, Sizova E. Rumen microbiome of cattle after introduction of ultrafine particles in feed. FEBS Open Bio. 2019;9(S1):416. doi: https://doi.org/10.1002/2211-5463.12672
  24. Miroshnikov S, Sizova E, Yausheva E, Uimin M, Konev A, Minin A, Yermakov A, Nikiyan H. Comparative toxicity of CuZn nanoparticles with different physical and chemical characteristics. Oriental Journal of Chemistry. 2019;35(3):973-981. doi: http://dx.doi.org/10.13005/ojc/350308
  25. Ognik K, Stępniowska A, Cholewińska E, Kozłowski K. The effect of administration of copper nanoparticles to chickens in drinking water on estimated intestinal absorption of iron, zinc, and calcium. Poultry Sci. 2016;95(9):2045-2051. doi: https://doi.org/10.3382/ps/pew200
  26. Pietroiusti A, Magrini A, Campagnolo L. New frontiers in nanotoxicology: Gut microbiota/microbiome-mediated effects of engineered nanomaterials. Toxicol Appl Pharmacol. 2016;299:90-95. doi: https://doi.org/10.1016/j.taap.2015.12.017
  27. Sahoo A, Swain R, Mishra SK. Effect of inorganic, organic and nano zinc supplemented diets on bioavailability and immunity status of broilers. Int J Adv. 2014;2(11):828-837.
  28. Sharma K, Chugh A. Legal aspects of nanobiotehnology inventions: An Indian perspective. SCRIPTed. 2009;6(2):433-448. doi: 10.2966/script.060209.433
  29. Takeda K, et al. Health effects of nanomaterials on next generation. Yakugaku Zasshi. 2011;131(2):229-236. doi: https://doi.org/10.1248/yakushi.131.229
  30. Zhao Y, Nalwa HS, editors. Nanotoxicology – interactions of nanomaterials with biological systems. American Scientific Pablishers; 2006:500 p.
  31. Zeineldin M, Barakat R, Elolimy A, Salem AZM, Elghandour MMY, Monroy JC. Synergetic action between the   rumen   microbiota   and   bovine  health.  Microb  Pathog.   2018;124:106-115. doi: https://doi.org/10.1016/j.micpath.2018.08.038

Kurilkina Marina Yakovlevna, Cand. Sci. (Biol.), Senior Researcher at the Testing Center of the Common Use Centre, Federal Research Centre of Biological Systems and Agrotechnologies of the Russian Academy of Sciences, 460000, Orenburg, Russia, 29, 9 Yanvarya St., tel.: 8(3532)30-81-77, e-mail: K_marina4@mаil.ru

Zavyalov Oleg Alexandrovich, Cand. Sci. (Agr.), Senior Researcher, Department of Technology of Beef Cattle Breeding and Beef Production, Federal Research Centre of Biological Systems and Agrotechnologies of the Russian Academy of Sciences, 460000, Orenburg, Russia, 29, 9 Yanvarya St., tel.: 8(3532)30-81-78, e-mail: oleg-zavyalov83@mail.ru

Atlanderova Kseniya Nikolaevna, Junior Researcher, Testing Center of the Common Use Centre, Federal Research Centre of Biological Systems and Agrotechnologies of the Russian Academy of Sciences, 460000, Orenburg, Russia, 29, 9 Yanvarya St, tel.: 8(3532)30-81-77, e-mail: atlander-kn@mail.ru

Kholodilina Tatyana Nikolaevna, Cand. Sci (Agr.), Head of the Testing Center of the Common Use Centre, Federal Research Centre of Biological Systems and Agrotechnologies of the Russian Academy of Sciences, 460000, Orenburg, Russia, 29, 9 Yanvarya St., tel.: 8(3532)30-81-77

Received: 9 March 2020; Accepted: 16 March 2020; Published: 31 March 2020

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