Marina Ya Kurilkina, Shamil G Rakhmatullin, Tatyana A Klimova, Dmitry G Deryabin, Georgy I Levakhin

Animal Husbandry and Fodder Production. 2023. Vol. 106, no 3. Р. 92-109.

 

Review article

Safety assessment of the use of phytochemicals during in vitro, in vivo experiments

and animal husbandry

 

Marina Ya Kurilkina1, Shamil G Rakhmatullin2, Tatyana A Klimova3, Dmitry G Deryabin4, 

Georgy I Levakhin5

1,2,3,4,5Federal Research Centre of Biological Systems and Agrotechnologies of the Russian Academy of Sciences, Orenburg, Russia

1k_marina4@mail.ru, https://orcid.org/0000-0003-0253-7867

2shahm2005@mail.ru, https://orcid.org/0000-0003-0143-9499

3klimovat91@mail.ru, https://orcid.org/0000-0003-4298-1663

4deryabin@cnikvi.ru, https://orcid.org/0000-0002-2495-6694

5Levakhing@internet.ru, https://orcid.org/0000-0002-8686-2183

Abstract. In view of the prohibition of antibacterial feed additives used in livestock farming at sub-inhibitory doses to increase productivity and prevent diseases, the need to develop new alternative substances has arisen. In Russia, this was facilitated by the Russian Federation Government Order No. 2045-r on the adoption of the "Strategy for the Prevention of Antimicrobial Resistance in the Russian Federation for the period up to 2030" (2017).

Possible non-antibiotic strategies for livestock production include the active use of probiotics and phytochemicals. At the same time, it is essentially important that plant compounds do not simply duplicate the action of antibiotics (with inherent negative effects associated with "selective pressure" on bacterial populations and the accompanying development of antibiotic resistance), but realize fundamentally different, not yet studied mechanisms of biological activity. One such mechanism is the participation of plant compounds in density-dependent communication processes in bacteria, often referred to by the term "quorum sensing" (QS). The utilization of various phytochemicals for safe agricultural products is supported by recent studies on the use of secondary metabolites (e.g. phenolic compounds, alkaloids, saponins, terpenoids, carotenoids, and quinones), etc. Promising substances for further research were identified, and a literature review was conducted to assess their safe use.

Keywords: phytochemicals, coumarin derivatives, vanillin, vanillic acid, gamma lactone, quercetin, alkylresorcinols

Acknowledgments: the work was performed in accordance to the plan of research works for 2023-2025 FSBRI FRC BST RAS (No. FNWZ-2022-0010).

For citation: Kurilkina MYa, Rakhmatullin ShG, Klimova TA, Deryabin DG, Levakhin GI. Safety assessment of the use of phytochemicals during in vitro, in vivo experiments and animal husbandry (review). Animal Husbandry and Fodder Production. 2023;106(3):92-109. (In Russ.). https://doi.org/10.33284/2658-3135-106-3-92

 

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Information about the authors:

Marina Ya Kurilkina, Cand. Sci. (Biology), Senior Researcher of the Testing Center, Federal Research Centre of Biological Systems and Agrotechnologies of the Russian Academy of Sciences, 29, 9 Yanvarya St., Orenburg, 460000, tel.: 8(3532)77-39-97.

Shamil G Rakhmatullin, Cand. Sci. (Biology), Senior Researcher of the Department of Feeding Farm Animals and Feed Technology named after S.G. Leushin, Federal Research Centre of Biological Systems and Agrotechnologies of the Russian Academy of Sciences, 460000, Orenburg, Russia, 29, 9 Yanvarya St., tel.: 89228157225.

Tatyana A Klimova, Head of the Laboratory of Microbiology of the Testing Center of the Central Collective Use Center, Federal Research Center for Biological Systems and Agrotechnologies of the Russian Academy of Sciences, 29, 9 Yanvarya St., Orenburg, 460000, tel.: +79878494166.

Dmitry G Deryabin, Dr. Sci. (Medical), Professor, Head of the Laboratory of Breeding and Genetic Research in Animal Husbandry, Federal Scientific Center for Biological Systems and Agrotechnologies of the Russian Academy of Sciences, 29, 9 Yanvarya St., Orenburg, 460000, tel.: 8(3532)30-81-79.

Georgy I Levakhin, Dr. Sci. (Biology), Professor, Chief Researcher of the Farm Animal Feeding and Feed Technology Department named after Leushin SG, Federal Research Centre of Biological Systems and Agrotechnologies of the Russian Academy of Sciences, 29, 9 Yanvarya St., Orenburg, 460000, tel.: 8(3532)30-81-79.

The article was submitted 14.08.2023; approved after reviewing 26.08.2022; accepted for publication 11.09.2023.

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