Korenyuga MV, Kuvanov TK, Kapitonova EA.

Animal Husbandry and Fodder Production. 2025. Vol. 108. No. 2. Р. 30-44.

doi:10.33284/2658-3135-108-2-30

Original article

Results of Azoxivet influence on the productivity and taxonomic composition of the intestinal microbiome of broiler chickens in postnatal ontogenesis

 

Maxim V Korenyuga1, Timur K Kuvanov2, Elena A Kapitonova3

1,2,3Moscow State Academy of Veterinary Medicine and Biotechnology – MVA by KI Skryabin, Moscow, Russia

1smith007@inbox.ru, https://orcid.org/0000-0002-3549-5969

2kuwanov_timur@mail.ru, https://orcid.org/0009-0002-2398-4412

3kapitonovalena1110@mail.ru, https://orcid.org/0000-0003-4307-8433

 

Abstract. The article presents the results of the influence of the immunomodulatory drug Azoxivet on dynamics of growth and development of broiler chickens of the "Ross-308" cross in postnatal ontogenesis, as well as the microflora of the caeca. The experimental work was carried out in the vivarium of the Federal State Budgetary Educational Institution of Higher Education "MGAVMiB-MVA named after. K.I. Scriabin." The experimental poultry was raised outdoors; the fattening period was 35 days. The immunomodulatory  drug  was  administered  oraly at a dose of 0.3 mg/kg live weight of the bird on days 1-, 8-, 12- and 17- simultaneously with the administration of a vaccine against infectious bronchitis of chickens (IBK), infectious bursal disease (IBD) and Newcastle disease (ND). The dynamics of postnatal ontogenesis of experimental broiler chickens was characterized by an increase in: average live weight - by 3.86 %, average daily gains – by 3.94%, EPEI – by 53.7 points, achieving livestock safety – 100% with a reduction in feed consumption per 1 kg of live weight gain - by 3.5%. The taxonomic diversity of microflora was determined using a modern method based on NGS sequencing. The composition of the microflora of the caeca of broiler chickens in the experimental group, by the end of the experiment, was distinguished by the smallest number of taxa with a higher microbial number.  The main representatives of normal flora at the family level changed their ratio in the microbiome. The proportion of microorganisms of the coprostanoligenes group (+18.27%), the Clostridia_UCG-014 family (+73.36%) and Erysipelotrichaceae increased significantly by 6.2 times.  On the contrary, a number of taxa decreased their percentage share or were completely absent in the samples of the experimental group.  The proportion  of  bacteria  of  the  family Lactobacillaceae decreased by 66.98 %, Ruminococcaceae – by 13.56%, Oscillospiraceae – by 11.26%, Monoglobaceae – by 43.75%, the families Anaerovoracaceae, Peptococcaceae, Staphylococcaceae, Corynebacteriaceae were absent in the samples of the experimental group. Based on the actual data obtained, we recommend the use of the immunomodulatory drug Azoxivet at a dose of 0.3 mg/kg of poultry live weight to increase the productivity, vitality and functional activity of the intestinal microbiome of broiler chickens.

Keywords: broiler chickens, productivity, immunomodulators, immunity, microflora, Azoxivet, sequencing, gastrointestinal tract, live weight, feed consumption, viability

For citation: Korenyuga MV, Kuvanov TK, Kapitonova EA. Results of Azoxivet influence on the productivity and taxonomic composition of the intestinal microbiome of broiler chickens in postnatal ontogenesis. Animal Husbandry and Fodder Production. 2025;108(2):30-44. (In Russ.). https://doi.org/10.33284/2658-3135-108-2-30

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Information about the authors:

Maxim V Korenyuga, Assistant of the Department of Zoohygiene and Poultry Farming named after A.K. Danilova, Moscow State Academy of Veterinary Medicine and Biotechnology – MBA named after K.I. Skryabin, 23 Academician Scriabin st., Moscow, 109472, tel. +7(915)1354764.

Timur K Kuvanov, Postgraduate student, 3rd year of preparation, full-time education, Moscow State Academy of Veterinary Medicine and Biotechnology – MBA named after K.I. Skryabin, 23 Academician Scriabin st., Moscow, 109472, tel.: +7(985)5129816.

Elena A Kapitonova, Dr Sci. (Biology), Associate Professor, Professor of the Department of Zoohygiene and Poultry Farming named after A.K. Danilova, Moscow State Academy of Veterinary Medicine and Biotechnology – MBA named after K.I. Skryabin, 23 Academician Scriabin st., Moscow, 109472, tel.: +7(926)925-75-78.

Contribution of the authors: the authors contributed equally to this article. The authors declare no conflicts of interests.

The article was submitted 11.03.2024; approved after reviewing 21.04.2025; accepted for publication 16.06.2025.

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