Tarasova EI, Notova SV, Momčilović B, Laryushina IE.

DOI: 10.33284/2658-3135-102-2-68

UDC 599.577.17

Acknowledgements:

Research was carried out according the plan of reasearch scientific works on 2019-2021 yy. FSBSI FRC BST RAS (No 0526-2019-0001)

Polymorphism of susceptibility genes to the effects of heavy metals in mammals (review)

EI Tarasova1,2, SV Notova1,2, B Momčilović3, IE Laryushina2

1 Federal Research Center for Biological Systems and Agrotechnologies of the Russian Academy of Sciences (Orenburg, Russia)

2Orenburg State University (Orenburg, Russia)

3 Institute of Sustainable Ecosystem Research and Development (Republic Croatia, Zagreb)

Summary. It is known that the implementation of genotype occurs against the background of various factors, such as feeding and animal welfare conditions. The adverse environmental situation, including the contamination of environment with heavy metals, often leads to a decrease in the productivity of farm animals. Genetic polymorphisms can be considered as internal factors contributing to the susceptibility of animals to the effects of heavy metals. However, the exact mechanism of this impact remains unexplored. Currently, several major proteins are directly or indirectly responsible for the body's resistance to the effects of heavy metals. These include metallothioneins (MT), glutathione system (GSH), selenoproteins, bivalent metal transporter 1 (DMT1), methylene tetrahydrofol-reductase (MTHFR), paraoxanase 1 (PON1). The review presents data on the presence of various single nucleotide polymorphisms in genes of metallotioneins, glutathione-related genes, methylenetetrahydrofluate reductase genes and the relation of these variations to the functioning of proteins. It is worth noting that there is often no consistency between the data obtained by various researchers, who studied genetic polymorphisms and their connection with the metabolism of heavy metals in the body. Accordingly, in order to make an accurate and correct conclusion, it is necessary to take into account the factors of animal origin and environmental influences that can greatly affect the results.

Key words: gene polymorphism, heavy metals, metal thioneins, glutathione system, methylene tetrahydrofolate reductase, para-oxanase 1, divalent metal transporter 1, detoxification.

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    Tarasova Ekaterina Ivanovna, Junior Researcher, Federal Research Center for Biological Systems and Agrotechnologies of the Russian Academy of Sciences, 460000, Orenburg, Russia, 29, 9 Januarya St.; Master of course I, Chemistry and Biology Faculty, Orenburg State University, 460018, Orenburg, Russia, 13 Pobedy Avenue

    Notova Svetlana Viktorovna, Dr. Sci. (Med.), Professor, First Deputy Director Federal Research Center for Biological Systems and Agrotechnologies of the Russian Academy of Sciences, 460000, Orenburg, Russia, 29, 9 Januarya St. e-mail: vniims.or@mail.ru; Professor of the Department of Biochemistry and Microbiology, Orenburg State University, 460018, Orenburg, Russia, 13 Pobedy Avenue

    Momčilović Berislav, Dr. Sci. (Med.), Institute of Sustainable Ecosystem Research and Development,Srebrnjak 59, 10 000, Zagreb, Croatia

    Laryushina Inara Jeksenderovna, Cand. Sci. (Med.), Senior Researcher at the Institute of Bioelementology, Orenburg State University, Orenburg State University, 460018, Orenburg, Russia, 13 Pobedy Avenue, е-mail: inhip@mail.ru

Received: 11 June 2019; Accepted: 17 June 2019; Published: 28 June 2019

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