Galina M Popova, Baer S Nurzhanov, Galimzhan K Duskaev
Animal Husbandry and Fodder Production. 2023. Vol. 106, no 2. Р. 152-175.
doi:10.33284/2658-3135-106-2-152
Review article
About the possibilities of using phytobiotic additives in the diets of farm animals (review)
Galina M Popova1, Baer S Nurzhanov2, Galimzhan K Duskaev3
1,2,3Federal Research Centre of Biological Systems and Agrotechnologies of the Russian Academy of Sciences, Orenburg, Russia
1galina577@rambler.ru
2baer.nurzhanov@mail.ru, https://orcid.org/0000-0003-3240-6112
3gduskaev@mail.ru, https://orcid.org/0000-0002-9015-8367
Abstract. In recent years, many researchers working in the field of feeding farm animals have paid attention to biologically active substances formed in plants - phytobiotics. Plants have been proven to improve immune system function, have a significant impact on animal health and increase productivity. Among the factors that determine the relevance of the development of highly effective phytobiotics in animal husbandry is the fact that the global use of medicinal plants as an alternative to various antimicrobials will not only protect animal health and maximize animal productivity, but also provide a solution to public health problems. Recently, Chinese medicinal herbs have attracted the attention of many researchers as possible sources of natural biologically active compounds in animal rearing. Biologically active compounds isolated from this plant are flavonoids, volatile terpenoids, oils and polysaccharides, which have a positive effect on the immune system and the body as a whole. The four main flavonoids of Scutellaria baicalensis, namely baicalein, baicalin, wogonoside, and wogonin, have shown antitumor, antibacterial, antiviral, antioxidant, antihypertensive, and hepatoprotective effects when assessed individually, suggesting the potential beneficial effects of the whole plant in animals. The purpose of the review article was to study the properties of phytobiotic additives and the question of the prospects for their use in feeding farm animals based on the analysis of modern domestic and foreign publications. Thus, phytobiotics, including Baikal skullcap, can be used in the diets of farm animals as an alternative to conventional antimicrobial drugs (antibiotics), as well as stimulators of cicatricial digestion.
Keywords: cattle, feeding, phytobiotics, productivity, chemical composition, Scutellaria baicalensis
Acknowledgments: the work was performed in accordance to the plan of research works for 2019-2023 FSBRI FRC BST RAS (No. 0761-2019-0005).
For citation: Popova GM, Nurzhanov BS, Duskaev GK. About the possibilities of using phytobiotic additives in the diets of farm animals (review). Animal Husbandry and Fodder Production. 2023;106(2):152-175. (In Russ.). https://doi.org/10.33284/2658-3135-106-2-152
References
- Akilova EA, Volozhanina MJu, Karpuhin MJu. Collection style of the flower garden. Youth and Science. 2017;6:8.
- Cherkashina NV, Drozdova LI, Makhortov VL, Vasilev PG, Dyomina LV, Sherbakov MG, Ilyazov AA, Sirik MS. Analysis of the current state of the problem of use of antibiotics as feed additive. Agrarian Bulletin of the Urals. 2011;3(82):39-42.
- Belyakova TN, Pechurkina DS. Functional products as a 21st century trend. Dairy Industry. 2020;2:46-47.
- Bykov VA. Plant biodiversity and human health. Bulletin of the Russian Academy of Sciences. 2016;86(6):553. doi: 10.7868/S0869587316060165
- Grebennikova OA, Paliy AYe, Logvinenko LA. Biologically active substances of Scutellaria Baicalensis Georgi of Nikita botanical gardens collection. Bull. of the State Nikit. Botan. Gard. 2015;117:60-66.
- Gryaznov MYu, Savchenko OM. Biological features of Scutellaria altissima L. under culture conditions in the Non-black Soil Zone of Russia. Bulletin KSAU. 2022;7(184):109-115. doi: 10.36718/1819-4036-2022-7-109-115
- Dudetskaya NA, Teslov LS, Anisimova NA. Flavonoid composition in species of Scutellaria (Lamiaceae) from Russian flora. Plant resources. 2010;46(2):159-174.
- Gubanov IA et al. Illustrated guide to plants of Central Russia. Volume 3: Covered seed (dicotyledonous: separate-petal) Moscow: Association of Scientific Publications KMK, Institute of Technological Research, 2004. 520 p. 2004: 520 p.
- Karimov AM, Popkov AS, Ostroushko YV, Turtaeva RI, Botirov EKh. Investigation of flavonoids of the root of the plant Scutellaria Intermedia Popov. Chemistry of Plant Raw Materials. 2018;4:89-94. doi: 10.14258/jcprm.2018043728
- Kabashnikava LF. Molecular mechanisms of plants and phytopathogens interaction: innate immunity. Journal of the Belarusian State University. Ecology. 2018;2:26-37.
- Kaledina MV. Obtaining prebiotic components for feed and food additives (Conference proseedings) Innovative solutions in agrarian science - a look into the future: materials of the XXIII Intern. sci.-prod. conf., (Maisky, May 28-29, 2019). Maisky: BSAU named after V.Ya. Gorin; 2019:13-15.
- Kalugina ZI. Market transformation of the agrarian sector of Russia: sociological discourse. Novosibirsk: IEOPP SO RAN; 2015: 341.
- Kurkin VA. Botanical-pharmacognostical characteristics of medicinal plant materials. Modern Phytomorphology. 2013;4:249-252.
- Novokreschinova IV, Gulyaeva YuN. Analysis of modern technologies of oil extracts (Conference proseedings) Innovations in the health of the nation: Sat. Materials V All-Russian. scientific-practical. conf. with international participation, (St. Petersburg, November 08-09, 2017). St. Petersburg: SPKhFA Publ.; 2017:296-299.
- Olennikov DN, Chirikova NK, Tankhaeva LM. Phenolic compounds of the Baikal skullcap (Scutellaria baicalensis Georgi). Chemistry of Plant Raw Materials. 2009;4:89-98.
- Belashova OV, Zaushintsena AV, Levanova LA, Zakharova YV, Mar AA, Asyakina LK. Determination of the antibacterial activity of flavonoids from callus Scutellaria galericulata L. for the development of a functional curd product. Proceedings of the Voronezh State University of Engineering Technologies. 2020;82.1(83):178-182. doi: 10.20914/2310-1202-2020-1-178-182
- Kudryavtsev IA, Pavlova OM, Gudkova MV, Oreshkin AE, Myasischeva NV. Characteristics of growth modulation effects of arachidonic acid metabolism inhibitors on mouse transplantable tumors with different profiles of synthesized eikosanoids in tumor tissue. Jornal of N. N. Blokhin Russian Cancer research center RAMS.2008;19(2-72):15-21.
- Asyakina LK et al. Prospects for using Siberian federal district plants in the production of functional food products. Bulletin of the South Ural State University. Ser. Food and Biotechnology, 2022;10(4):5-17. doi: 10.14529/food220401
- Piraner YG, Buzuk GN. Study of microscopic evidence of Scutellaria Galericulata herb. Bulletin of Pharmacy. 2015;3(69):46-49.
- Pirogov VV, Topuriya GM. Study of the effect of germivite on some indicators of enzymatic metabolism in bulls. Bulletin of the Bryansk State Agricultural Academy. 2015;2-1:28-31.
- Pichugin VS. Scutellaria Altissima L. in the Crimean flora, distribution and morphology. Bull. of the State Nikit. Botan. Gard. 2012;105:17-20.
- Rogov IA et al. Antioxidant-containing food product from Baikal scull-cap extract: pat. 2228673 Russian Federation. Application. 20.06.2003; publ. 20.05.2004.
- Platonov VG, Chernov NV. Functional foodstuffs market. Scientific Journal of OrelSIET. 2019;2(30):21-24.
- Pharmacy is easy and understandable. Decree of the Government of the Russian Federation of December 29, 2021 No. 2544 "Development of the pharmaceutical and medical industry. Available from: https://pharmmedprom.ru/news/plan-razvitiya-rossiiskoi-farmotrasli-farma-2030-gotov/ [cited 2023 June 6]
- Filipchuk OD, Glinushkin AP, Zhemchuzhin SG et al. Implemintation of adaptive plant protection from pests in the conditions of sanatorium-resort zone. Russian Journal of Agricultural and Socio-Economic Sciences. 2017;10(70): 269-273. doi: 10.18551/rjoas.2017-10.38
- Sokolov AS, Sokolova LA. About new and the most rare species of Tambov region flora. Report four. Tambov University Reports. Series Natural and Technical Sciences. 2014;19(3):1035-1043.
- Ryazanov VA, Kurilkina MYa, Duskaev GK, Gabidulin VM. Phytobiotics as an alternative to antibiotics in animal husbandry (review). Animal Husbandry and Fodder Production. 2021;104(4):108-123. doi: 10.33284/2658-3135-104-4-108
- Vakhitov KhM, et al. Phytotherapy of respiratory diseases: modern possibilities. Pediatrician's Practice. 2017;(5):6-9.
- Chirikova NK, Olennikov DN. Microscopic study of Baikal skullcap (Scutellaria Baicalensis Georgi) herb. Pharmacy. 2009;3:16-19.
- Abdikerimova G, Moldabekov B. The role of animal husbandry in the sustainable development of agriculture for food security and nutrition. Deutsche Internationale Zeitschrift für zeitgenössische Wissenschaft. 2021;11-2:4-7. doi: 10.24412/2701-8369-2021-11-2-4-7
- Akbarian-Tefaghi M, Ghasemi E, Khorvash M. Performance, rumen fermentation and blood metabolites of dairy calves fed starter mixtures supplemented with herbal plants, essential oils or monensin. Journal of Animal Physiology and Animal Nutrition. 2018;102(3):630-638. doi: https://doi.org/10.1111/jpn.12842
- Beardsworth A, Bryman A, Keil Т, et al. Women, men and food: The significance of gender for nutritional attitudes and choices. British food Journal. 2002;104(7):470-491. doi: 10.1108/00070700210418767
- Beauchemin KA, McGinn SM. Methane emissions from beef cattle: Effects of fumaric acid, essential oil, and canola oil1. Journal of Animal Science. 2006;84(6):1489-1496. doi: 10.2527/2006.8461489x
- Biernasiak J, Śliżewska K, Libudzisz Z. Negatywne skutki stosowania antybiotyków. Postęp Nauk Rol. 2010;62(3):105-17.
- Bozov PI, Coll J. neo-Clerodane diterpenoids from Scutellaria altissima. Nat Prod Commun. 2015;10(1):13-16.
- Brogna DMR, Tansawat R, Cornforth D, Ward R, Bella M, Luciano G, Priolo A, Villalba J. The quality of meat from sheep treated with tannin- and saponin-based remedies as a natural strategy for parasite control. Meat Science. 2014;96(2 Part A):744-749. https://doi.org/10.1016/j.meatsci.2013.10.019
- Busquet M, Calsamiglia S, Ferret A, Kamel C. Screening for effects of plant extracts and active compounds of plants on dairy cattle rumen microbial fermentation in a continuous culture system. Anim Feed Sci Technol. 2006;123-124 (Part 2):597-613. doi: https://doi.org/10.1016/j.anifeedsci.2005.03.008
- Calsamiglia S, Busquet M, Cardozo PW, Castillejos L, Ferret A. Invited review: Essential oils as modifiers of rumen microbial fermentation. J Dairy Sci. 2007;90(6):2580-2595. doi: 10.3168/jds.2006-644
- Chen J, Mao Y, Guo K, Wu H, Song X, Qu M, Lan L, Luo J. The synergistic effect of traditional Chinese medicine prescription and rumen-protected γ-aminobutyric acid on beef cattle under heat stress. J Anim Physiol Anim Nutr (Berl). 2021;105(5):807-815. doi: 10.1111/jpn.13507
- Dong P, Zhang Y, Gu J, Wu W, Li M, Yang J et al. Wogonin, an active ingredient of Chinese herb medicine Scutellaria baicalensis, inhibits the mobility and invasion of human gallbladder carcinoma GBC-SD cells by inducing the expression of maspin. Journal of Ethnopharmacology. 2011;137(3):1373-1380. doi: 10.1016/j.jep.2011.08.005
- Ferdous MF, Arefin MS, Rahman MM, Ripon MMR, Rashid MH, Sultana MR, Rafiq K. Beneficial effects of probiotic and phytobiotic as growth promoter alternative to antibiotic for safe broiler production. Journal of Advanced Veterinary and Animal Research. 2019;6(3):409-415. doi: 10.5455/javar.2019.f361
- Fernandez-Novo A, Fargas O, Loste JM, Sebastian F, Perez-Villalobos N, Pesantez-Pacheco JL, et al. Pregnancy loss (28-110 days of pregnancy) in Holstein cows: A retrospective study. Animals. 2020;10:925. https://doi.org/10.3390/ani10060925
- Franz C, Chizzola R, Novak J, Sponza S. Botanical species being used for manufacturing plant food supplements (PFS) and related products in the EU member states and selected third countries. Food Funct. 2011;2(12):720-730. doi: 10.1039/c1fo10130g
- Georgieva Y, Katsarova M, Stoyanov P, et al. Metabolite profile and antioxidant activity of some species of genus scutellaria growing in Bulgaria. Plants (Basel). 2021;10(1):45. doi:10.3390/plants10010045
- Hashemzadeh-Cigari F, Khorvash M, Ghorbani GR, Kadivar M, Riasi A, Zebeli Q. Effects of supplementation with a phytobiotics-rich herbal mixture on performance, udder health, and metabolic status of Holstein cows with various levels of milk somatic cell counts. J Dairy Sci. 2014;97(12):7487-7497. doi: 10.3168/jds.2014-7989
- Hlel TB, Robles AR, Smaali I, Marzouki MN. Role of phytomedicines in metabolic disorders. In: Bhat RA, Hakeem KhR, Dervash MA, editors. Phytomedicine. Academic Press. 2021;14:389-407.
- Huang S-T, Wang C-Y, Yang R-C, Chu C-J, Wu H-T, Pang J-HS. Wogonin, an active compound in Scutellaria baicalensis, induces apoptosis and reduces telomerase activity in the HL-60 leukemia cells. Phytomedicine. 2010;17(1):47-54.doi: 10.1016/j.phymed.2009.06.005
- Jahani-Azizabadi H, Baraz H, Bagheri N, Ghaffari MH. Effects of a mixture of phytobiotic-rich herbal extracts on growth performance, blood metabolites, rumen fermentation, and bacterial population of dairy calves. J. Dairy Sci. 2022;105:5062-5073. doi: 10.3168/jds.2021-20687
- Jing L, Zhang R, Liu Y, Zhu W, Mao S. Intravenous lipopolysaccharide challenge alters ruminal bacterial microbiota and disrupts ruminal metabolism in dairy cattle. Br J Nutr. 2014;112(2):170-182. doi: 10.1017/S000711451400066X
- Jungbauer A, Medjakovic S. Anti-inflammatory properties of culinary herbs and spices that ameliorate the effects of metabolic syndrome. Maturitas. 2012;71(3):227-239. doi: 10.1016/j.maturitas.2011.12.009
- Kalantar M. The Importance of flavonoids in ruminant nutrition. Archives of Animal Husbandry & Dairy Science. 2018;1(1):AAHDS.MS.ID.000504. doi: 10.33552/AAHDS.2018.01.000504
- Khiaosa-Ard R, Zebeli Q. Meta-analysis of the effects of essential oils and their bioactive compounds on rumen fermentation characteristics and feed efficiency in ruminants. Journal of Animal Science.2013;91(4):1819-1830. doi: https://doi.org/10.2527/jas.2012-5691
- Kumar A, Roy B, Lakhani GP, Jain A. Evaluation of dried bread waste as feedstuff for growing crossbred pigs. Vet World. 2014;7(9):698-701. doi: 10.14202/vetworld.2014.698-701
- Kuralkar P, Kuralkar SV. Role of herbal products in animal production - An updated review. J Ethnopharmacol. 2021;278:114246. doi: 10.1016/j.jep.2021.114246
- Li W, Xu X, Zhang H, Ma C, Fong H, van Breemen R, Fitzloff J. Secondary metabolites from Andrographis paniculata. Chemical and Pharmaceutical Bulletin. 2007;55(3):455-458. doi: 10.1248/cpb.55.455
- Liu H, Ye F, Sun Q, Liang H, Li C, Li S et al. Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitro. Journal of Enzyme Inhibition and Medicinal Chemistry. 2021;36(1):497-503. doi: 10.1080/14756366.2021.1873977
- Mansilla FI, Ficoseco CA, Miranda MH, Puglisi E, Nader-Macías MEF, Vignolo GM, Fontana CA. Administration of probiotic lactic acid bacteria to modulate fecal microbiome in feedlot cattle. Scientific Reports. 2022;12(1):12957. doi: 10.1038/s41598-022-16786-z
- Manuelian CL, Pitino R, Simoni M, et al. Plant Feed Additives as Natural Alternatives to the Use of Synthetic Antioxidant Vitamins on Livestock Mammals' Performances, Health, and Oxidative Status: A Review of the Literature in the Last 20 Years. Antioxidants (Basel). 2021;10(9):1461. doi: 10.3390/antiox10091461
- Markowiak P, Śliżewska K. The role of probiotics, prebiotics and synbiotics in animal nutrition. Gut pathogens. 2018;10(1):21. doi:10.1186/s13099-018-0250-0
- Milentyeva IS, Fedorova AM, Larichev TA, Altshuler OG. Biologically active compounds in Scutellaria baicalensis L. callus extract: phytochemical analysis and isolation. Foods and Raw Materials. 2023;11(1):172-186. http://doi.org/10.21603/2308-4057-2023-1-564
- Mohammadhosseini M, Sarker SD, Akbarzadeh A. Chemical composition of the essential oils and extracts of Achillea species and their biological activities: A review. Journal of Ethnopharmacology. 2017;199:257-315. doi: 10.1016/j.jep.2017.02.010
- Olagaray KE, Brouk MJ, Mamedova LK, Sivinski SE, Liu H, Robert F, Dupuis E, Zachut M, Bradford BJ. Dietary supplementation of Scutellaria baicalensis extract during early lactation decreases milk somatic cells and increases whole lactation milk yield in dairy cattle. PLoS One. 2019;14(1):e0210744. doi: 10.1371/journal.pone.0210744
- Pei T, Yan M, Huang Y, Wei Y, Martin C, Zhao Q. Specific flavonoids and their biosynthetic pathway in Scutellaria baicalensis. Frontiers in Plant Science. 2022;13:866282. doi: 10.3389/fpls.2022.866282
- Rehman K, Yaqub M, Sheikh A, Arshad M. Extraction and evaluation of peroxidases from various vegetable sources. Int J Agric Biol. 1999;1(3):170-173
- Ren H, Vahjen W, Dadi T, Saliu EM, Boroojeni FG, Zentek J. synergistic effects of probiotics and phytobiotics on the intestinal microbiota in young broiler chicken. Microorganisms. 2019;7(12):684. doi: 10.3390/microorganisms7120684
- Shang X, He X, He X, Li M, Zhang R, Fan P et al. The genus Scutellaria an ethnopharmacological and phytochemical review. Journal of Ethnopharmacology. 2010;128(2):279-313. doi: 10.1016/j.jep.2010.01.006
- Shikov AN, Tsitsilin AN, Pozharitskaya ON, Makarov VG, Heinrich M. Traditional and current food use of wild plants listed in the Russian pharmacopoeia. Front Pharmacol. 2017;8:841. doi:10.3389/fphar.2017.00841
- Shin HS, Bae MJ, Choi DW, Shon DH. Skullcap (Scutellaria baicalensis) extract and its active compound, wogonin, inhibit ovalbumin-induced Th2-mediated response. Molecules. 2014;19(2):2536-2545. doi:10.3390/molecules19022536)
- Shin HS, Bae MJ, Jung SY, Shon DH. Inhibitory effect of skullcap (Scutellaria baicalensis) extract on ovalbumin permeation in vitro and in vivo. Food Chem. 2013;140(1-2):22-30. doi: 10.1016/j.foodchem.2013.01.042
- Simoni M, Goi A, Pellattiero E, Mavrommatis A, Tsiplakou E, Righi F, Manuelian CL. Long-term administration of a commercial supplement enriched with bioactive compounds does not affect feed intake, health status, and growth performances in beef cattle. Archives Animal Breeding. 2022;65(1):135-144. doi: 10.5194/aab-65-135-2022
- Stefańska B, Sroka J, Katzer F, Goliński P, Nowak W. The effect of probiotics, phytobiotics and their combination as feed additives in the diet of dairy calves on performance, rumen fermentation and blood metabolites during the preweaning period. Animal Feed Science and Technology. 2021;272:114738. doi: 10.1016/j.anifeedsci.2020.114738
- Su H, Yao S, Zhao W, Li M, Liu J, Shang W, Xu Y. Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients. Acta Pharmacologica Sinica. 2020;41(9):1167-1177. doi:10.1038/s41401-020-0483-6
- Topuria LY, Topuria GM, Pirogov VV. Effect of phytobiotic -Germivit on the functional state of cattle. Revista Facultad Nacional de Agronomía Medellín. 2021;74(2):9549-9561. doi: 10.15446/rfnam.v74n2.85369
- Truszczyński M, Pejsak Z. Wpływ stosowania u zwierząt antybiotyków na lekooporność bakterii chorobotwórczych dla człowieka. Med Weter. 2006;62:1339-1343.
- Tsiplakou E, Pitino R, Manuelian CL, Simoni M, Mitsiopoulou C, De Marchi M et al. Plant feed additives as natural alternatives to the use of synthetic antioxidant vitamins in livestock animal products yield, quality, and oxidative status: a Review. Antioxidants. 2021;10(5):780. https://doi.org/10.3390/antiox10050780
- Turek C, Stintzing FC. Stability of essential oils: a Review. Comprehensive Reviews in Food Science and Food Safety. 2013;12(1):40-53. doi: 10.1111/1541-4337.12006
- Ulrich E. Study of quality and safety parameters of phytobiotics based on medicinal plant extracts. In: Current trends of agricultural industry in global economy: Proceedings of XIX international scientific and practical conference, Kemerovo, 2020, 8 to 9 December; Kemerovo: Kuzbass State Agricultural Academy; 2020:258-264. doi: 10.32743/agri.gl.econ.2020.258-264
- Wall EH, Bravo DM, 1554 Supplementation with rumen-protected capsicum oleoresin increases milk production and component yield in lactating dairy cows. Journal of Animal Science. 2016;94(suppl_5):755. doi: https://doi.org/10.2527/jam2016-1554
- Wang X, Xie L, Long J et al. Therapeutic effect of baicalin on inflammatory bowel disease: A review. J Ethnopharmacol. 2022;283:114749. doi: 10.1016/j.jep.2021.114749
- Wang Z-L, Wang S, Kuang Y, Hu Z-M, Qiao X, Ye M. A comprehensive review on phytochemistry, pharmacology, and flavonoid biosynthesis of Scutellaria baicalensis. Pharmaceutical Biology. 2018;56(1):465-484. doi: 10.1080/13880209.2018.1492620
- Wen W, Alseekh S, Fernie AR. Conservation and diversification of flavonoid metabolism in the plant kingdom. Current Opinion in Plant Biology. 2020;55:100-108. doi: 10.1016/j.pbi.2020.04.004
- Wu Z, Huang W, Qin E et al. Comprehensive identification and expression profiling of circular RNAs during nodule development in Phaseolus vulgaris. Front Plant Sci. 2020;11:587185. doi: 10.3389/fpls.2020.587185
- Xu Z, Gao R, Pu X, Xu R, Wang J, Zheng S et al. Comparative genome analysis of Scutellaria baicalensis and scutellaria barbata reveals the evolution of active flavonoid biosynthesis. Genomics, Proteomics & Bioinformatics. 2020;18(3):230-240. doi: 10.1016/j.gpb.2020.06.002
- Yang R, Liu H, Bai C, Wang Y, Zhang X, Guo R, Wang Y. Chemical composition and pharmacological mechanism of Qingfei Paidu Decoction and Ma Xing Shi Gan Decoction against Coronavirus Disease 2019 (COVID-19): in silico and experimental study. Pharmacological Research. 2020;157:104820. doi: 10.1016/j.phrs.2020.104820
- Yausheva EV, Duskaev GK, Levakhin GI, Nurzhanov BS, Rysaev AF, Rakhmatullin SG, Inchagova KS, Yuldashbaev YA. Evaluation of the effects of plant extracts on cattle rumen microbiome. IOP Conference Series: Earth and Environmental Science. 2019;341:012165. doi: 10.1088/1755-1315/341/1/012165
- Yin B, Li W, Qin H, Yun J, Sun X. The use of chinese skullcap (Scutellaria baicalensis) and its extracts for sustainable animal production. Animals (Basel). 2021;11(4):1039. doi: 10.3390/ani11041039
- Zhao Q, Chen XY, Martin C. Scutellaria baicalensis, the golden herb from the garden of Chinese medicinal plants. Science Bulletin. 2016;61(18):1391-1398. doi: 10.1007/s11434-016-1136-5
- Zhao T, Tang H, Xie L et al. Scutellaria baicalensis Georgi. (Lamiaceae): a review of its traditional uses, botany, phytochemistry, pharmacology and toxicology. J Pharm Pharmacol. 2019;71(9):1353-1369. doi: 10.1111/jphp.13129
- Zhou Y, Hirotani M, Yoshikawa T, Furuya T. Flavonoids and phenylethanoids from hairy root culture of Scutellaria baicalensis. Phytochemistry. 1997;44(1):83-87.
Information about the authors:
Galina M Popova, Master's student of the Department of Farm Animal Feeding and Feed Technology named after Leushin SG, Federal Research Centre of Biological Systems and Agrotechnologies of the Russian Academy of Sciences, 29, 9 Yanvarya St., Orenburg, 460000, tel.: 8(3532)30-81-79.
Baer S Nurzhanov, Dr. Sci. (Agriculture), Senior Researcher, Department of Farm Animal Feeding and Feed Technology named after Leushin SG, Federal Research Centre of Biological Systems and Agrotechnologies of the Russian Academy of Sciences, 29, 9 Yanvarya St., Orenburg, 460000, tel.: 8(3532)30-81-79.
Galimzhan K Duskaev, Dr. Sci. (Biology), Professor of Russian Academy of Sciences, Leading Researcher of the Department of Farm Animal Feeding and Feed Technology named after S.G. Leushin, Federal Research Centre for Biological Systems and Agrotechnologies of the Russian Academy of Sciences; 29, 9 Yanvarya St., Orenburg, 460000, tel.: 8(3532)30-81-70.
The article was submitted 18.04.2023; approved after reviewing 09.06.2023; accepted for publication 13.06.2023.
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